When each individual makes a small act of charity, like getting the COVID-19 vaccine, every gesture added together can transform the world, Pope Francis said in a global ad campaign.

“Being vaccinated with vaccines authorized by the competent authorities is an act of love. And contributing to ensure the majority of people are vaccinated is an act of love — love for oneself, love for one’s family and friends, love for all people,” he said in a public service announcement released Aug. 18 in Rome.

The video message was part of a global effort by the U.S.-based nonpartisan, nonprofit Ad Council and the COVID Collaborative’s “It’s Up To You” campaign to increase people’s confidence in COVID-19 vaccines by reminding them that the vaccines are safe, effective and save people’s lives. The Vatican’s Dicastery for Integral Human Development also cooperated with the educational initiative.

The video in Spanish with English, Spanish and Portuguese subtitles features Pope Francis and six cardinals and archbishops from North and South America. Archbishop José H. Gomez of Los Angeles, president of the U.S. Conference of Catholic Bishops, is among them.